Hippeastrum reticulatum (Amaryllidaceae): Alkaloid profiling, biological activities and molecular docking

Luciana R. Tallini, Edison H. Osorio, Vanessa Dias Dos Santos, Warley De Souza Borges, Marcel Kaiser, Francesc Viladomat, José Angelo S. Zuanazzi, Jaume Bastida

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The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. The aim of this work was to perform the first detailed study of the alkaloid constituents of Hippeastrum reticulatum (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhibitory activities of the epimers (6α-hydroxymaritidine and 6β-hydroxymaritidine). Twelve alkaloids were identified in H. reticulatum: eight known alkaloids by GC-MS and four unknown (6α-hydroxymaritidine, 6β-hydroxymaritidine, reticulinine and isoreticulinine) by NMR. The epimer mixture (6α-hydroxymaritidine and 6β-hydroxymaritidine) showed low activity against all protozoan parasites tested and weak AChE-inhibitory activity. Finally, a molecular docking analysis of AChE and BuChE proteins showed that isoreticulinine may be classified as a potential inhibitory molecule since it can be stabilized in the active site through hydrogen bonds, π-π stacking and hydrophobic interactions.

Idioma originalInglés
Número de artículo2191
EstadoPublicada - 1 dic 2017

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Tallini, L. R., Osorio, E. H., Dos Santos, V. D., De Souza Borges, W., Kaiser, M., Viladomat, F., Zuanazzi, J. A. S., & Bastida, J. (2017). Hippeastrum reticulatum (Amaryllidaceae): Alkaloid profiling, biological activities and molecular docking. Molecules, 22(12), [2191]. https://doi.org/10.3390/molecules22122191