Design and synthesis of a new coumarin-based 'turn-on' fluorescent probe selective for Cu +2

Olimpo García-Beltrán; Natalia Mena; Leidi C. Friedrich; José Carlos Netto-Ferreira; Víctor Vargas; Frank H. Quina; Marco T. Núñez; Bruce K. Cassels

doi:10.1016/j.tetlet.2012.07.082

Design and synthesis of a new coumarin-based 'turn-on' fluorescent probe selective for Cu ⁺²

Olimpo García-Beltrán, Natalia Mena, Leidi C. Friedrich, José Carlos Netto-Ferreira, Víctor Vargas, Frank H. Quina, Marco T. Núñez, Bruce K. Cassels

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

42 Citas (Scopus)

Resumen

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	5280-5283
Número de páginas	4751
Publicación	Tetrahedron Letters
DOI	https://doi.org/10.1016/j.tetlet.2012.07.082
Estado	Publicada - 26 sep 2012
Publicado de forma externa	Sí

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10.1016/j.tetlet.2012.07.082

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@article{8b475d77909640ad82c83db39848565b,

title = "Design and synthesis of a new coumarin-based 'turn-on' fluorescent probe selective for Cu +2",

abstract = "The novel coumarin-based 'turn-on' fluorescent probe (E)-3-(2,5- dimethoxybenzylideneamino)-7-hydroxy-2H-chromen-2-one (MGM) was designed, synthesized, and characterized. This compound shows high selectivity for Cu +2, combined with a large fluorescence enhancement upon binding to Cu 2+. Benesi-Hildebrand and Job plots demonstrate that the stoichiometry of the Cu 2+ complex formed is 2:1. Preliminary studies employing epifluorescence microscopy demonstrated that Cu +2 could be imaged in human neuroblastoma SH-SY5Y cells treated with MGM. {\textcopyright} 2012 Elsevier Ltd. All rights reserved.",

author = "Olimpo Garc{\'i}a-Beltr{\'a}n and Natalia Mena and Friedrich, {Leidi C.} and Netto-Ferreira, {Jos{\'e} Carlos} and V{\'i}ctor Vargas and Quina, {Frank H.} and N{\'u}{\~n}ez, {Marco T.} and Cassels, {Bruce K.}",

year = "2012",

month = sep,

day = "26",

doi = "10.1016/j.tetlet.2012.07.082",

language = "American English",

pages = "5280--5283",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

}

Design and synthesis of a new coumarin-based 'turn-on' fluorescent probe selective for Cu ⁺². / García-Beltrán, Olimpo; Mena, Natalia; Friedrich, Leidi C.; Netto-Ferreira, José Carlos; Vargas, Víctor; Quina, Frank H.; Núñez, Marco T.; Cassels, Bruce K.

En: Tetrahedron Letters, 26.09.2012, p. 5280-5283.

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

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T1 - Design and synthesis of a new coumarin-based 'turn-on' fluorescent probe selective for Cu +2

AU - García-Beltrán, Olimpo

AU - Mena, Natalia

AU - Friedrich, Leidi C.

AU - Netto-Ferreira, José Carlos

AU - Vargas, Víctor

AU - Quina, Frank H.

AU - Núñez, Marco T.

AU - Cassels, Bruce K.

PY - 2012/9/26

Y1 - 2012/9/26

N2 - The novel coumarin-based 'turn-on' fluorescent probe (E)-3-(2,5- dimethoxybenzylideneamino)-7-hydroxy-2H-chromen-2-one (MGM) was designed, synthesized, and characterized. This compound shows high selectivity for Cu +2, combined with a large fluorescence enhancement upon binding to Cu 2+. Benesi-Hildebrand and Job plots demonstrate that the stoichiometry of the Cu 2+ complex formed is 2:1. Preliminary studies employing epifluorescence microscopy demonstrated that Cu +2 could be imaged in human neuroblastoma SH-SY5Y cells treated with MGM. © 2012 Elsevier Ltd. All rights reserved.

AB - The novel coumarin-based 'turn-on' fluorescent probe (E)-3-(2,5- dimethoxybenzylideneamino)-7-hydroxy-2H-chromen-2-one (MGM) was designed, synthesized, and characterized. This compound shows high selectivity for Cu +2, combined with a large fluorescence enhancement upon binding to Cu 2+. Benesi-Hildebrand and Job plots demonstrate that the stoichiometry of the Cu 2+ complex formed is 2:1. Preliminary studies employing epifluorescence microscopy demonstrated that Cu +2 could be imaged in human neuroblastoma SH-SY5Y cells treated with MGM. © 2012 Elsevier Ltd. All rights reserved.

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