A selective thioxothiazolidin-coumarin probe for Hg2+ based on its desulfurization reaction. Exploring its potential for live cell imaging

Margarita E. Aliaga; Marcela Gazitua; Andrea Rojas-Bolaños; Marcial Fuentes-Estrada; Diego Durango; Olimpo García-Beltrán

doi:10.1016/j.saa.2019.117372

A selective thioxothiazolidin-coumarin probe for Hg²⁺ based on its desulfurization reaction. Exploring its potential for live cell imaging

Margarita E. Aliaga, Marcela Gazitua, Andrea Rojas-Bolaños, Marcial Fuentes-Estrada, Diego Durango, Olimpo García-Beltrán

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Sensing the most toxic heavy metal (mercury) has attracted a lot of attention in recent years due to its extreme harmfulness to both human health and the environment. Thus, we reported herein the synthesis, spectroscopic and kinetic characterization, and biological evaluation of a new thioxothiazolidin coumarin derivative (ILA92), which undergoes a desulfurization reaction induced by mercuric ions (Hg²⁺). This process is the origin of a selective sensing of Hg²⁺ ions in aqueous solution by colorimetric and fluorescent methods. Furthermore, the probe showed great potential for imaging Hg²⁺ in living cells.

Original language	English
Article number	117372
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	224
DOIs	https://doi.org/10.1016/j.saa.2019.117372
State	Published - 5 Jan 2020

Keywords

Colorimetric fluorescent dye
Desulfurization reaction
Hg ions
Naked eye sensor
Thioxothiazolidin coumarin derivative

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Aliaga, M. E., Gazitua, M., Rojas-Bolaños, A., Fuentes-Estrada, M., Durango, D., & García-Beltrán, O. (2020). A selective thioxothiazolidin-coumarin probe for Hg²⁺ based on its desulfurization reaction. Exploring its potential for live cell imaging. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 224, [117372]. https://doi.org/10.1016/j.saa.2019.117372

Aliaga, Margarita E. ; Gazitua, Marcela ; Rojas-Bolaños, Andrea ; Fuentes-Estrada, Marcial ; Durango, Diego ; García-Beltrán, Olimpo. / A selective thioxothiazolidin-coumarin probe for Hg²⁺ based on its desulfurization reaction. Exploring its potential for live cell imaging. In: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 2020 ; Vol. 224.

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Aliaga, ME, Gazitua, M, Rojas-Bolaños, A, Fuentes-Estrada, M, Durango, D & García-Beltrán, O 2020, 'A selective thioxothiazolidin-coumarin probe for Hg²⁺ based on its desulfurization reaction. Exploring its potential for live cell imaging', Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, vol. 224, 117372. https://doi.org/10.1016/j.saa.2019.117372

A selective thioxothiazolidin-coumarin probe for Hg²⁺ based on its desulfurization reaction. Exploring its potential for live cell imaging. / Aliaga, Margarita E.; Gazitua, Marcela; Rojas-Bolaños, Andrea; Fuentes-Estrada, Marcial; Durango, Diego; García-Beltrán, Olimpo.

In: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Vol. 224, 117372, 05.01.2020.

Research output: Contribution to journal › Article › peer-review

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T1 - A selective thioxothiazolidin-coumarin probe for Hg2+ based on its desulfurization reaction. Exploring its potential for live cell imaging

AU - Aliaga, Margarita E.

AU - Gazitua, Marcela

AU - Rojas-Bolaños, Andrea

AU - Fuentes-Estrada, Marcial

AU - Durango, Diego

AU - García-Beltrán, Olimpo

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AB - Sensing the most toxic heavy metal (mercury) has attracted a lot of attention in recent years due to its extreme harmfulness to both human health and the environment. Thus, we reported herein the synthesis, spectroscopic and kinetic characterization, and biological evaluation of a new thioxothiazolidin coumarin derivative (ILA92), which undergoes a desulfurization reaction induced by mercuric ions (Hg2+). This process is the origin of a selective sensing of Hg2+ ions in aqueous solution by colorimetric and fluorescent methods. Furthermore, the probe showed great potential for imaging Hg2+ in living cells.

KW - Colorimetric fluorescent dye

KW - Desulfurization reaction

KW - Hg ions

KW - Naked eye sensor

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JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

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