TY - JOUR
T1 - A selective thioxothiazolidin-coumarin probe for Hg2+ based on its desulfurization reaction. Exploring its potential for live cell imaging
AU - Aliaga, Margarita E.
AU - Gazitua, Marcela
AU - Rojas-Bolaños, Andrea
AU - Fuentes-Estrada, Marcial
AU - Durango, Diego
AU - García-Beltrán, Olimpo
PY - 2020/1/5
Y1 - 2020/1/5
N2 - Sensing the most toxic heavy metal (mercury) has attracted a lot of attention in recent years due to its extreme harmfulness to both human health and the environment. Thus, we reported herein the synthesis, spectroscopic and kinetic characterization, and biological evaluation of a new thioxothiazolidin coumarin derivative (ILA92), which undergoes a desulfurization reaction induced by mercuric ions (Hg2+). This process is the origin of a selective sensing of Hg2+ ions in aqueous solution by colorimetric and fluorescent methods. Furthermore, the probe showed great potential for imaging Hg2+ in living cells.
AB - Sensing the most toxic heavy metal (mercury) has attracted a lot of attention in recent years due to its extreme harmfulness to both human health and the environment. Thus, we reported herein the synthesis, spectroscopic and kinetic characterization, and biological evaluation of a new thioxothiazolidin coumarin derivative (ILA92), which undergoes a desulfurization reaction induced by mercuric ions (Hg2+). This process is the origin of a selective sensing of Hg2+ ions in aqueous solution by colorimetric and fluorescent methods. Furthermore, the probe showed great potential for imaging Hg2+ in living cells.
KW - Colorimetric fluorescent dye
KW - Desulfurization reaction
KW - Hg ions
KW - Naked eye sensor
KW - Thioxothiazolidin coumarin derivative
UR - http://www.scopus.com/inward/record.url?scp=85069695523&partnerID=8YFLogxK
U2 - 10.1016/j.saa.2019.117372
DO - 10.1016/j.saa.2019.117372
M3 - Artículo
AN - SCOPUS:85069695523
VL - 224
JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
SN - 1386-1425
M1 - 117372
ER -